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The pH optimum for the active saturable transport is 5.56.0, which explains why antacids seem to reduce folate absorption

It is important to understand, however, that a calorie deficit itself is not a direct physiological cause of diarrhoea

Gu L, Sun Y, Wu T, Chen G, Tang X, Zhao L, He L, Hu Z, Sun L, Pan F, Yin Z

Additionally, depression is associated with a 36.8% increase in coronary heart disease and a 32.9% increase in stroke risk among patients with diabetes [27]