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Recent studies have demonstrated that SGLT2 inhibitors trigger autophagy via the mammalian target of rapamycin (mTOR), 5adenosine monophosphate-activated protein kinase (AMPK), sirtuin 1 (SIRT1), and hypoxia-inducible factor (HIF) signaling pathways (257259)

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N-Acetylcysteine improves renal dysfunction, ameliorates kidney damage and decreases blood pressure in salt-sensitive hypertension