These mechanisms occur within hours after GCs administration and may lead to hyperglycemia, even in individuals without a prior history of glucose abnormalities ( Figure 1 The clinical impact of hyperglycemia during GCs therapy has been well established, with multiple studies reporting increased morbidity and mortality, including higher rates of infection, cardiovascular events and prolonged hospitalisations ( Although glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are not currently recommended in SID by major guidelines, their mechanism of action makes them promising candidates to counteract the metabolic impacts of steroids
Did side effects remain manageable
Neuropsychiatr Dis Treat (2016) 12:182736.10.2147/NDT.S109637 105 LasserRADirksBNasrallahHKirschCGaoJPucciMLet alAdjunctive lisdexamfetamine dimesylate therapy in adult outpatients with predominant negative symptoms of schizophrenia: open-label and randomized-withdrawal phases
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Since 2021, GLP-1s have eroded metformin as the preferred first-line therapy for many patients, despite metformins lower cost and oral administration
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