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Additionally, human clinical trials highlighted that in a fraction of FMT recipients, particularly melanoma patients who earlier responded to ICI treatment but later developed ICI-resistance, FMT restored the ICI non-responsiveness (266, 267)

Polyphenols are the most abundant antioxidants in the human diet

How does this align with my curriculum

Overproduction of ROS is stimulated, and consequently, OS is triggered during inflammation because of the large number of cytokines and chemokines secreted by inflammatory cells

Naringin, like other polyphenols, undergo extensive metabolism in the gut, thereby enhancing the growth of beneficial bacteria such as Bifidobacteria and Lactobacillus [172]

most importantly of which is platelet-rich plasma (PRP)