Yet practical protocols use milligram doses, thousands of times higher
The skin acts as a barrier and a reservoir, leading to a slower, more sustained release into the local tissues
Activation of D4 could also influence T rm numbers, as this receptor can regulate expression of Kruppel-like factor 2 (Sarkar et al., 2006), a transcription factor whose downregulation is essential for T rm development
doi: 10.3389/fphys.2020.595516 33 Habza-KowalskaEKaczorAAukJMatosiukDGawlik-DzikiU
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