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Apart from inhibiting DPP-4 enzyme, alogliptin also affects several signaling mechanisms to exhibit protective effects in patients with diabetes-induced complications

Diabetes Care 2016;39:204250.PubMed 71

Impairment of autophagy may be associated with follicular miniaturization in androgenetic alopecia by inducing premature catagen

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it also improved liver function by reversing hepatic steatosis features in histopathological specimens of DIO mice

Measuring binding affinity by R2KD Recent work by Liu and colleagues introduced a novel LO-NMR method that can be used to quantitatively determine the dissociation constant (K D ) of a ligand for a protein from measured R2 values of ligand nuclei at a range of ligand concentrations 40