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Glutathione binds to these metals via its sulfhydryl group, forming conjugates that are excreted in bile and urine [2][6]

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Therefore, the balance between ROS production and antioxidant substances in the epididymis is essential for sperm development and maturation

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This release leads to increased vascular permeability, plasma protein extravasation, white blood cell infiltration, vasodilation, mast cell breakdown, stimulation of meningeal pain receptors, and further release of inflammatory substances (10)

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