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The trade-off is randomization: participants may be assigned to placebo or a lower dose arm, and the protocol imposes constraints on concurrent medications and lifestyle modifications that may not reflect individual patient circumstances

These symptoms are typically transient and subside as the body adjusts to therapy

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Allowing for a dropout of 15% over the study period, the trial required 103 participants per group (206 in total)

Ro's protocol-driven approach ensures standardized risk assessment

Yes, but the hepatitis A vaccine is typically covered under Medicare Part D prescription drug coverage, like the shingles vaccine, not under Medicare Part B, which covers many other vaccines