Any damage to its physical integrity constitutes the initiating event of pathological processes, with tight junctions and the basement membrane being the two primary targets of attack
[DOI] [PMC free article] [PubMed] [Google Scholar] 75.Markovic J., Borrs C., Ortega ., Sastre J., Via J., Pallard F.V
To differentiate between the potential involvement of these two consequences in H 2 O 2 -induced sensitization to TNF hepatotoxicity, we first exposed HepG2 cells to (BSO), a potent inhibitor of gamma-glutamylcysteine synthetase, the rate-limiting enzyme in the glutathione synthesis pathway (Fig
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Mitochondrial iron metabolism: the crucial actors in diseases
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