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After reconstitution, aliquot to prevent repeated freezethaw cycles

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Consistently with its low efficacy in beta-arrestin recruitment, which is involved in receptor endocytosis, the ability of tirzepatide to induce GLP-1R internalization is approximately 40% that of native GLP-1 while its effect on GIPR is similar to native GIP

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Safety issues of tirzepatide (pancreatitis and gallbladder or biliary disease) in type 2 diabetes and obesity: A systematic review and meta-analysis