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Both discoidal HDL particles and mature spherical HDL particles can also promote free cholesterol efflux from another transporter, ATP-binding cassette transport G1 (ABCG1), which is thought to reside on sub-cellular organelles as opposed to the plasma membrane (Figure 2) (690,691)

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239 Mitochondrial iron accumulation lead by Fe-S cluster deficiency can further induce iron-mediated ROS increasing and subsequent ferroptosis that due to lipid peroxides accumulation