Mechanistically, resmetirom enhances hepatic lipid oxidation, rapidly reduces liver fat content, and modulates intrahepatic metabolic and fibrogenic pathways, with relatively modest effects on body weight [20,21]
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Several proteins were regulated with semaglutide, after accounting for changes in body weight and HbA 1c at end of trial, suggesting effects of semaglutide on the proteome beyond weight loss and glucose lowering
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