Dose-related effects on the rat fetus (structural abnormalities and reduced body weight) occurred only at higher dosages, equal to or greater than 150 mg/kg (more than 2344-times the 10 mg clinical dose, based on AUC), which were associated with maternal toxicity
J Pathol (2012) 226(2):35264
Escobar-Morreale HF, Alvarez-Blasco F, Botella-Carretero JI, Luque-Ramirez M
This delayed and inadequate labeling forms the basis for failure-to-warn claims, which argue that had patients and doctors received proper warnings about gastroparesis and vision loss risks, many would have chosen alternative diabetes medications or weight loss treatments
Three new studies investigated the link between GLP-1s and eye disease, but each employed distinct methods and arrived at different conclusions
doi: 10.2337/diaclin.34.3.148