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These fragments stimulate inflamed synovium cells (synoviocytes, macrophages, lymphocytes) to secrete cytokines, chemokines, and lipid mediators, as well as more ROS and MMPs, which can directly degrade the components of the cartilage matrix or dysregulate the metabolism of chondrocytes, leading to an imbalance between cartilage matrix degradation and synthesis

Ranisavljev M, Todorovic N, Ostojic J, Ostojic SM

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Cryopreservation of human ovarian tissue using dimethylsulphoxide and propanediol-sucrose as cryoprotectants

243 Despite being linked to T-cell dysfunction and poor cancer prognosis, obesity has paradoxically been shown to enhance the response to anti-PD-1/PD-L1 immunotherapy