PMCID: PMC9654015
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Therefore, we performed pharmacokinetic studies of BPC157 in beagle dogs following single IV administration at a dose of 6 g/kg, single IM administration at doses of 6, 30, or 150 g/kg, and repeated IM administration at a dose of 30 g/kg for seven consecutive days
Across rat stroke, rat traumatic-brain-injury, and mouse multiple-sclerosis (EAE) models, thymosin beta-4 consistently increased oligodendrocyte progenitor cells and mature oligodendrocytes and augmented remyelination, apparently through p38 MAPK signaling and myelin-basic-protein synthesis