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Limitations Zepbound should not be used in patients with a history or family history of thyroid cell tumors (MTC) and endocrine cancers (MEN 2 syndrome)

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Preclinical studiesincluding both animal models and in vitro experimentssupport these findings by demonstrating mechanisms involving improved endothelial nitric oxide availability, reduced oxidative stress, inhibition of inflammatory cytokines, and protection against lipid peroxidation [7,9]

Morning dosing allows side effects to resolve during waking hours and aligns with natural appetite patterns

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