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Intercurrent illnesses or medication changes (including addition of sedating medications or unavailability of regular symptomatic AD medications): This estimand will be analysed in participants who undergo follow-up RBANS assessment at 180 days (+0, 10 days) and who have taken at least 80% of the study medication, and where there have been no intercurrent events blindly adjudicated as affecting cognition (principal stratum strategy) Secondary estimand epigenetic change 1

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C677T polymorphism in the MTHFR gene (A222V, rs1801133) is associated with a decrease in enzymatic activity to 3570% in homozygotes

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Moreover, the peroxisome proliferator-activated receptor (PPAR) regulates OCTN2 expression by binding to the PPAR-response element within the first intron (Qu et al., 2014)