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The medication is administered as a once-weekly subcutaneous injection, with a recommended starting dose of 2.5 mg for 4 weeks, then 5 mg, with stepwise escalation to a maximum of 15 mg as tolerated, according to the UK SmPC
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Moreover, while pressurized liquid extraction reduces solvent use and extraction time compared to traditional methods, incomplete extraction of certain compounds can still occur, necessitating complementary techniques or further refinement (77)
However, oral administration may be less effective because peptides can be broken down by the digestive system before reaching their target
10.1016/j.cell.2016.09.014 Summary Keywords glucagon-like peptide-1, glucagon-like peptide-1 receptor agonist, glucagon, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis Citation Seghieri M, Christensen AS, Andersen A, Solini A, Knop FK and Vilsbll T (2018) Future Perspectives on GLP-1 Receptor Agonists and GLP-1/glucagon Receptor Co-agonists in the Treatment of NAFLD
