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Minor inflammation or soreness occurs because the needle punctures muscles and tissues, potentially causing localized irritation
Second, it can stimulate the innate immune recognition mechanisms of the host, including the induction of the NF-B signaling pathway via TLR2/TLR4, thus promoting the release of proinflammatory cytokines, including IL-6 and TNF-, which initiates an inflammatory cascade response 138
Use sunscreen during the day, as brightening ingredients may increase sun sensitivity
Berninger B, Costa MR, Koch U, Schroeder T, Sutor B, Grothe B et al
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