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Experiments performed elsewhere did not find an increase in cellular glutamate content upon GSIS in either INS-1 cells or isolated rat islets [70]

Beyond serving as substrates, KBs and ketogenic diets (KD) may enhance mitochondrial function by promoting mitochondrial biogenesis via NAD-dependent signalling pathways involving SIRT1/2/3, AMPK, PGC-1, and FOXO1/3a, and by increasing mitochondrial respiration through PGC-1mediated effects on respiratory complexes (e.g., complex I/II)

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Jung MK, Okekunle AP, Lee JE et al (2021) Role of branched-chain amino acid metabolism in tumor development and progression

In line with this observation, GLP-1 excursions during the MMT were completely identical between PBH and non PBH (Fig