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The SURMOUNT-1 Phase 3 trial demonstrated that tirzepatide 15mg weekly produced 20.9% mean body weight reduction versus 3.1% placebo

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In this context, eating patterns are a key determinant of weight loss success and maintenance, yet evidence on how best to combine pharmacotherapy with specific dietary strategies remains limited [14, 17]

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We want you to lose weight, yes, but we also want to correct the basic genetic etiology of the insulin resistance, and that is why we need new drugs in the insulin-resistance field, DeFronzo said