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Technical difficulties in manufacturing two separate peptide drugs or engineered dual-agonist drugs of high purity, stability, and consistency needed for subcutaneous injection make the development and commercialization of dual GLP-1/amylin combination drugs a significant manufacturing challenge

Regular monitoring for signs and symptoms of pancreatitis is essential, and the medication should be discontinued immediately if pancreatitis is suspected

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As with any investigational substance, unknown or idiosyncratic responses cannot be excluded, and the long-term safety of BPC-157 has not been formally characterised

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