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Lyons KE

In the study, people with significant insulin resistance experienced reductions in HbA1c across retatrutide doses, with stronger effects at higher doses

Nonetheless, the long-term administration of GLP-1 RAs requires vigilant monitoring to minimize potential adverse effects, including gastrointestinal disturbances and pancreatic overstimulation

K.MehraM

It is critical to emphasise that dedicated cardiovascular outcomes trials (CVOTs) the gold standard for assessing a drug's long-term effect on events such as heart attack and stroke have not yet been completed for retatrutide

Hydration remains essential, as water helps minimize side effects and supports the medications effectiveness