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The compounds were shown to disrupt KRAS activity by inhibiting guanine nucleotide exchange factor (GEF)-catalyzed nucleotide exchange and blocking effector binding, effectively stabilizing the protein in its inactive state

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Ozempic is produced in multiple doses ranging from 0.25mg to 1mg, whereas Wegovy comes in pre-filled pens containing 1 pen fill of 0.75mg

The International Council for Harmonisation (ICH) has developed guidelines applicable to peptide therapeutics, reducing duplicative requirements across regulatory jurisdictions