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Alcohol Res: Curr Rev 38(2):163 Blanco AM, Valls SL, Pascual M, Guerri C (2005) Involvement of TLR4/type I IL-1 receptor signaling in the induction of inflammatory mediators and cell death induced by ethanol in cultured astrocytes

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These resistance-associated genes also overlapped with those identified in an additional genetic screen seeking to identify drivers of estrogen-independence - with CSK also as a shared top hit suggesting that the identified genes are relevant for general endocrine resistance (and perhaps G1 arrest), rather than representing a giredestrant-specific resistance program 36

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The propensity score was constructed from age at the index date (continuous), sex, race, region, number of RMS relapses in the preindex period (0, 1, 2+), prior DMT in the preindex period, RMS disability in the preindex period, Deyo-Charlson comorbidity index (DCCI) in the preindex period (continuous), and Psychiatric Diagnosis Group index in the preindex period (continuous)