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About 10% of tirzepatide participants had a heart-rate increase above 20 bpm during escalation, compared with 3% on placebo. A lean Japanese cohort reached +10 to +13 bpm, and 23% of Japanese participants at 15 mg crossed the abnormal-pulse threshold versus 7% of other participants, despite only 17% higher exposure. Lean and East Asian bodies showed greater cardiovascular sensitivity than exposure alone predicted

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This global pharmacovigilance study of over 60,000 reports identified that the median age of drug-related AP patients was 54 years (IQR 4166 years), which is generally consistent with previous studies of AP conducted in Europe and the United States

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Guo H, Li WPG, Wang C,Li D, Sheng X,Yuan L