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Lower doses are typically used initially to assess tolerance and effectiveness

This may be relevant to internalization

Cells were serum starved for 24 h and then stimulated with 30 nM dimeric macrocycle or 0.25 nM hHGF in the presence of 5% FBS and 10 M BrdU for 20 h

Six (14%) patients in the control group and 4 (12.5%) patients in the intervention group had university degrees, and a significant difference regarding education level ( p = 0.029