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Endocrine Reviews

Heres a general guideline on how often B12 shots are administered: For Severe Deficiency : Initially, B12 shots may be given daily or weekly to rapidly boost levels in someone who has a significant deficiency

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Overgrowth of bacteria: Some people develop vitamin B 12 deficiency as a result of conditions that slow the movement of food through the intestines (diabetes, scleroderma, strictures, diverticula), allowing intestinal bacteria to multiply and overgrow in the upper part of the small intestine