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As with most medications, weight loss injections have side effects that gradually reduce as time goes on

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(PubMed) Mechanistically, one investigation found that semaglutide accesses discrete brainstem and hypothalamic regions (via circumventricular organs rather than bulk crossing the blood-brain barrier) and triggers cFos activation in multiple nuclei involved in appetite control and reward, thereby altering neural pathways that regulate feeding behaviour

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However, US physicians rarely make the diagnosis, mainly due to poor awareness and understanding

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Key dietary strategies include: Protein optimisation : Increasing protein intake to around 1.01.5 g per kg per day based on target body weight helps preserve lean muscle mass during weight loss and enhances satiety

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