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11.2 Application of nanotechnology in CUL5-targeted therapy Given that CUL5 is widely involved in normal cellular physiological functions and its neddylation pathway partially overlaps with other Cullin family members (e.g., CUL1), existing targeting strategies often suffer from suboptimal specificity and are prone to off-target effects (172)

Clinically, PD appears as an advancing movement disorder with characteristic motor symptoms such as bradykinesia, resting tremor, muscle stiffness, and postural instability [2]

The Phase 3 SURMOUNT trials, which enrolled over 6,000 participants, did not exclude patients taking antioxidant supplements (including glutathione precursors like N-acetylcysteine)

doi: 10.1073/pnas.1604458113

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