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Interleukin-6 (IL-6) regulation is considered to be independent of the aging-related gene P53 and instead is modulated directly by the DNA damage response (DDR), influencing the IL-6 signaling complex expression on cell surfaces (Rodier et al., 2009)

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This is also known as oxidative damage, and it can interfere with normal cellular function and contribute to the development of numerous diseases and aging processes ( The human body employs a sophisticated array of antioxidants to combat oxidative stress

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