reduced glutathione function antioxidant system. a Schematics for the reduction of With its role in the bodys detoxifying processes oxidized vs reduced glutathione Modelling

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Its primary role is to combat free radicals roaming in the blood thus reducing oxidative stress

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5-Hydroxytryptamine4 receptor agonists and colonic motility

Molecules 25 (1), 676

It plays a crucial role in cellular events such as inflammatory responses, altered cell growth, and apoptosis ( Figure 1 ) ( Figure 1 The role of alterations in the antioxidant system in the pathogenesis of vitiligo has been extensively studied ( CAT gene and reduced catalase activity have also been associated with several metabolic diseases, such as diabetes, hypertension, and peroxisomal/peroxisomal diseases ( On the other hand, the chronic OS will produce an excessive accumulation of ROS, which in turn induces the production of damage-associated molecular patterns (DAMPs) and the release of melanosomal antigens that activate innate immunity ( + T cells are activated through HSP70i activation and antigen presentation by mature dendritic cells ( + T cells are recruited to induce melanocyte apoptosis ( + T cells ( These findings suggest that oxidative stress plays a vital role in the pathogenesis of vitiligo