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Possible anti-inflammatory benefits

Lai et al

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Particularly noteworthy is that FOXO4 influences not only lifespan but also the quality of aging through its interaction with the protein p53commonly referred to as the "guardian of the genome." This interaction regulates whether cells remain in a senescent, metabolically inactive state or undergo programmed cell death (apoptosis)

Such designs may also promote anti-inflammatory programs, for example, by supporting M2 macrophage polarization, thereby helping to re-establish immune tolerance while preserving the ability to respond to non-self signals [28]