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The authors are grateful for the financial support from the National Natural Science Foundation of China (81873312) and Jointly Guided Project of Heilongjiang Provincial Natural Science Foundation of China (JJ2022LH1048)

This work is partially supported by the National Cancer Institute (NCI) of the National Institutes of Health (NIH) (R01CA057341 (C.V.D)), The Leukemia and Lymphoma Society LLS 6106-14 (C.V.D.) and the Abramson Family Cancer Research Institute

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