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Label transfer of primary hypothalamic neurons onto hPSC-derived neurons was performed by finding the 10 nearest primary hypothalamic neurons neighbours for each hPSC-derived neurons using the queryKNN function from the BiocNeighbors R package on the integrated space, followed by assigning the most common primary hypothalamic neuron cell type from the neighbouring cells

The primary mechanism involves appetite regulation through central nervous system effects

Testosterone also plays a crucial role in maintaining muscle mass and bone density

Established Safety Profile Across all clinical studies, AOD-9604 demonstrated excellent safety and tolerability

Despite its prevalence in this population, disparities in diagnosis, treatment access, and long-term outcomes remain profound

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