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The binding of leptin to LEP-R also activates the phosphoinositide 3-kinase (PI3K) and mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling cascades, as well as the JAK2-STAT signaling cascade (57)

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OP 23 Advances in insulin therapy 133 Ado09, a co-formulation of pramlintide and insulin A21G improves post-prandial glucose and body weight versus insulin aspart in type 1 diabetes G