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In humans, the half-life is similar in healthy subjects and obese patients with type 2 diabetes (120)

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NO system modulation: It regulates nitric oxide synthesis, contributing to vascular protection and inflammation reduction

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Being a potential potent inhibitor of LRRK2 kinase activity with low risk for off-target side effects, Vit B12 supplementation in patients with PD (PwPD) seems appealing and encourages future clinical trials to investigate this potent effect as such evidence remains restrained to animal models (Green and Christine 2019) (Fig