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We did not adjust this model for data that did not meet tests for normality, as mixed linear models are generally robust to violations of this assumption (Knief and Forstmeier, 2021)

[DOI] [PubMed] [Google Scholar] 131.Yang S., Wang X., Contino G., Liesa M., Sahin E., Ying H., Bause A., Li Y., Stommel J.M., Dellantonio G., et al

Additionally, quercetin can upregulate pyroptosis-related genes (GSDMD, GSDME, cleaved CASP1, NLRP3) and activate the pyroptosis pathway to suppress cell proliferation (85)

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The use of amlodipine in the murine model and clinical case reversed IOC remodeling, demonstrating that amlodipine is effective adjuvant therapy for IOC