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While the body usually produces adequate glutathione, stress, poor diet, or a chronic health condition can reduce glutathione levels

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Further, high energetic demand in the hippocampus and entorhinal cortex for memory and learning plasticity likely generates high levels of ROS [6] and the need for robust autophagic control of proteostasis, largely powered by GTP [7]

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[22] observed that the GIP receptor contains a functional PPAR- response element in the promoter region of the gene in INS-1 cells