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The GLP-1 analogs liraglutide and semaglutide reduce atherosclerosis in ApoE-/- and LDLr-/- mice by a mechanism that includes inflammatory pathways

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It is foreseeable that GLP-1 weight loss drugs with superior effects and safety will become the next blockbuster

The SCALE phase 3a trials discussed in this paper were designed prior to the recent regulatory requirements for intercurrent events and hence patients discontinuing randomized injections or violating the protocol were withdrawn from the trials and only invited in for a landmark visit to assess the body weight

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