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Originally designed as a mechanism for pharmacies to share in network performance-based risk, DIR fees evolved into broad retroactive clawbacks assessed months after dispensing, making it impossible for pharmacies to know their actual reimbursement at the time of sale

Robinson TE, Berridge KC

Ingredients such as dihydroberberine, gymnema sylvestre, green tea phytosome, chromium, and GBB are commonly used in formulas focused on appetite control, glucose metabolism, thermogenesis, and cravings

Exclude them to manage costs

Its multimodal mechanisms of action and excellent tolerability make it a promising candidate for adjunctive or standalone treatment in mood disorders

2024 Jan 15;17:227-230