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Some private insurance plans may offer partial coverage Provincial drug plans may cover GLP-1 medications for specific medical indications Weight-loss-only use may not be covered Patients should confirm coverage directly with their insurance provider and healthcare professional

In severe cases, patients may develop visual disturbances due to optic neuropathy

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In this review, we will discuss current findings to support the hypothesis that in most scenarios, combination with other therapeutic modalities will be required to optimise efficacy and current evidence for the molecular mechanisms that underpin potential combinations

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