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Clean reads were aligned to the human hg38 reference genome using bowtie2 software (v2.2.4)

Because GLP-1 medicines can also reduce insulin resistance, I had to reduce my long-acting insulin by about 20% to avoid hypoglycemia, which can be severe unless insulin therapy is modified before starting

Nasal spray, or intranasal administration, is easier

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doi: 10.1111/j.1476-5381.2012.01971.x 32 IsacsonRNielsenEDannaeusKBertilssonGPatroneCZachrissonOet al

Unlike semaglutide (a large peptide requiring specialized absorption technology), orforglipron is a small molecule that absorbs more reliably through the GI tract, can be taken with food, and is cheaper to manufacture