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When present, classic findings include: Unilateral leg swelling (edema, increased limb circumference) Pain or tenderness along the course of the deep vein, often exacerbated by walking or dorsiflexion (Homans sign low specificity, rarely documented) Erythema or skin warmth over the affected limb Skin discoloration cyanosis (phlegmasia cerulea dolens in massive DVT) or pallor/blanching (phlegmasia alba dolens) Dilated superficial veins (collateral vessel prominence) Pitting edema distal to obstruction Upper extremity DVT may present with arm swelling, cyanosis, heaviness, or Paget-Schroetter syndrome (effort thrombosis in athletes/manual workers following strenuous use)

Overexpression of these mi-RNAs increased ECM degradation, the inflammatory response, and MMP-13 expression in chondrocytes

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doi: 10.1002/ajhb.20520 20 HorimotoACaiJThorntonTFranceschiniN

SIZE: 8.4 oz / 250mL DIRECTION: 1