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Additionally, Candida albicans secretes aspartyl proteinases (SAPs) that degrade mitochondrial structural and metabolic proteins, further impairing mitochondrial integrity and energy production ( Cryptococcus neoformans utilizes a polysaccharide capsule to suppress mitochondrial metabolism in macrophages, decreasing mtROS production and blunting fungicidal activity ( 4.2 Fungal-mediated disruption of mitochondrial bioenergetics and ETC function Mitochondrial OXPHOS serves as a key energy source for immune cell function, particularly for macrophages and dendritic cells engaged in antifungal defense

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O., Levine, J