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Combined with the short plasma half-life of injected GHK (minutes to ~2 hours before peptidase cleavage and copper redistribution to albumin/ceruloplasmin), this is why topical 12% serum beats subcutaneous injection for localized skin and scalp endpoints

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10.1172/JCI75836 232 XieC.JinJ.BaoX.ZhanW

Oncogene 27(16):23002311 Hagenbuchner J, Kuznetsov A, Hermann M et al (2012) FOXO3-induced reactive oxygen species are regulated by BCL2L11 (Bim) and SESN3 [J]