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While the adult fat body is concentrated in a sheet of tissue underneath the abdominal cuticle, the fat body of the metamorphosing pupae is diffuse in the hemolymph-filled body cavity during the remodeling and formation of adult tissues 39,40

Endogenous ROS generally contain superoxide (O 2 ), hydrogen peroxide (H 2 O 2 ), hydroxyl radicals, and oxygen anions (Shadel and Horvath, 2015)

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While Akkermansia is often considered a beneficial microbe in metabolic contexts, in PD its overgrowth might reflect (or contribute to) excessive mucin erosion and gut barrier dysfunction [156]

Supplemental Figure 3B, C

doi: 10.1016/S0140-6736(14)61468-9 132 KimMPlattMJShibasakiTQuagginSEBackxPHSeinoSet al