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GLP1 receptor agonist use was shown to be associated with a reduction in the risk for progression to cirrhosis in patients with MASLD and diabetes, and who started the medication early in the course of their disease, 13 leading the FDA to approve semaglutide for this condition in August 2025

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10.3390/biomedicines10030524 Summary Keywords MASLD, MASH, NAFLD, NASH, microbiome, dysbiosis, metabolic syndrome Citation Dua A, Kumari R, Singh M, Kumar R, Pradeep S, Ojesina AI and Kumar R (2025) Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): the interplay of gut microbiome, insulin resistance, and diabetes