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The study also has several limitations

GI side effects may temporarily increase during the transition because tirzepatide adds GIP receptor activation

Seek immediate medical attention if you are experiencing any extreme symptoms of constipation

Smriti Choudhary, M.D

Treatment regimen estimand This estimand is used to assess the average treatment effect of bimagrumab, semaglutide or bimagrumab plus semaglutide for all randomized participants at week 48, regardless of treatment adherence and/or premature discontinuation of study treatment or placebo

For many people using semaglutide, its considered a long-term treatment, similar to how other chronic conditions are managed over time