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Consistent absorption and systemic availability remain uncertain, and human pharmacokinetic data are lacking

10.2174/1574888X16666210714152730 Curr Stem Cell Res Ther

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133 Importantly, S6K1 depletion, which is a component of mTOR signaling, also leads to a prolonged lifespan in mice

The thresholds for Iwp (high), Iwp (low) and Ip (low) were 200, 140, 80 for 4HNE, 200, 125, 75 for Cytochrome c, 200, 125, 75 for ferritin, 200, 115, 70 for ferroportin, 200, 150, 70 for GPX4 and 200, 135, 70 for NCOA4, respectively